Understanding CRY2 interactions for optical control of intracellular signaling

Liting Duan; Jen Hope; Qunxiang Ong; Hsin-Ya Lou; Namdoo Kim; Comfrey McCarthy; Victor Acero; Michael Z. Lin; Bianxiao Cui

doi:10.1038/s41467-017-00648-8

Nature Communications (Sep 2017)

Understanding CRY2 interactions for optical control of intracellular signaling

Liting Duan,
Jen Hope,
Qunxiang Ong,
Hsin-Ya Lou,
Namdoo Kim,
Comfrey McCarthy,
Victor Acero,
Michael Z. Lin,
Bianxiao Cui

Affiliations

Liting Duan: Department of Chemistry, Stanford University
Jen Hope: Department of Chemistry, Stanford University
Qunxiang Ong: Department of Chemistry, Stanford University
Hsin-Ya Lou: Department of Chemistry, Stanford University
Namdoo Kim: Department of Bioengineering, Stanford University
Comfrey McCarthy: Department of Psychology, Northeastern University
Victor Acero: Department of Engineering Science, Pennsylvania State University
Michael Z. Lin: Department of Bioengineering, Stanford University
Bianxiao Cui: Department of Chemistry, Stanford University

DOI: https://doi.org/10.1038/s41467-017-00648-8
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Cryptochrome 2 (CRY2) can form light-regulated CRY2-CRY2 homo-oligomers or CRY2-CIB1 hetero-dimers, but modulating these interactions is difficult owing to the lack of interaction mechanism. Here the authors identify the interactions facilitating homo-oligomers and introduce mutations to create low and high oligomerization versions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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