Comparison of Trazodone, Diazepame and Dibenzepine Influences on Rat Brain Beta-Endorphins Content

Abstract

The aim of our study was to establish the extent of influence of different psychotropic drugs to brain β-endorphins in experimental animals. The study was performed on albino Wistar rats (weight 250 g), treated with different psychoactive drugs. RIA technique was employed for quantification of brain β-endorphins. Brain β-endorphins were higher in experiment group treated with trazodone (929 pg/g ± 44,43; X±SD), and dibenzepine (906,63 pg/g ± 74,06), yet with lower brain content in rats treated with diazepame (841,55 pg/g ± 68,47), compared to brain β-endorphins content of control group treated with saline solution (0,95% NaCl) (873,5 pg/g ± 44,89). Significant differences were obtained comparing brain β-endorphins of trazodone vs. diaze-pame treated animals, with diazepame group having lower values (p<0,02). This study showed differences in changes of rat brain β-endorphins contents when different psy-choactive drugs are used. Therefore, we consider that β-endorphins could be used for evaluation of effects of psychoactive drugs, as a useful parameter in therapy with these psycho pharmaceuticals.

Keywords

• β-endorphins
• rat
• psychotropic drugs
• trazodone
• diazepame
• diben-zepine