Constituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

Arnauld Kenfack Djoumessi; Raymond Ngansop Nono; Beate Neumann; Hans-Georg Stammler; Gabin Thierry Mbahbou Bitchagno; Noella Molisa Efange; Celine Nguefeu Nkenfou; Lawrence Ayong; Bruno Ndjakou Lenta; Norbert Sewald; Pépin Nkeng-Efouet-Alango; Jean Rodolphe Chouna

doi:10.3390/metabo13020298

Metabolites (Feb 2023)

Constituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities

Arnauld Kenfack Djoumessi,
Raymond Ngansop Nono,
Beate Neumann,
Hans-Georg Stammler,
Gabin Thierry Mbahbou Bitchagno,
Noella Molisa Efange,
Celine Nguefeu Nkenfou,
Lawrence Ayong,
Bruno Ndjakou Lenta,
Norbert Sewald,
Pépin Nkeng-Efouet-Alango,
Jean Rodolphe Chouna

Affiliations

Arnauld Kenfack Djoumessi: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Raymond Ngansop Nono: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Beate Neumann: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Hans-Georg Stammler: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Gabin Thierry Mbahbou Bitchagno: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Noella Molisa Efange: Centre Pasteur du Cameroun, Yaounde P.O. Box 1274, Cameroon
Celine Nguefeu Nkenfou: Department of Biology, Higher Teacher Training College, University of Yaoundé 1, Yaoundé P.O. Box 47, Cameroon
Lawrence Ayong: Centre Pasteur du Cameroun, Yaounde P.O. Box 1274, Cameroon
Bruno Ndjakou Lenta: Department of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé P.O. Box 47, Cameroon
Norbert Sewald: Department of Chemistry, Organic and Bioorganic Chemistry-OC3, Bielefeld University, P.O. Box 100131, 33501 Bielefeld, Germany
Pépin Nkeng-Efouet-Alango: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
Jean Rodolphe Chouna: Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon

DOI: https://doi.org/10.3390/metabo13020298
Journal volume & issue: Vol. 13, no. 2
p. 298

Abstract

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The chemical investigation of the EtOH extract from the stem bark of Trichilia monadelpha (Thonn.) J. J. De Wilde afforded two new limonoids (1 and 2): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (1) and (6R)-1-O-deacetylkhayanolide E (2), together with eleven known compounds (3–13), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including Staphylococcus aureus and Plasmodium falciparum. Fraction E (n-Hex/EtOAc 30:70, v/v) showed significant activity against S. aureus ATCC 25923 with a MIC value of 3.90 µg/mL, while one of its constituents (epicatechin (9)) exhibited significant activity with MIC values of 7.80 µg/mL. Interestingly, grandifotane A (6) (IC50 = 1.37 µM) and khayanolide D (5) (IC50 = 1.68 µM) were highly active against the chloroquine-sensitive/sulfadoxine-resistant plasmodium falciparum 3D7 strain, unlike their corresponding plant extract and fractions.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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