BME Frontiers (Jan 2023)

Organotypic Models for Functional Drug Testing of Human Cancers

  • Yu Ling Huang,
  • Lindsay K. Dickerson,
  • Heidi Kenerson,
  • Xiuyun Jiang,
  • Venu Pillarisetty,
  • Qiang Tian,
  • Leroy Hood,
  • Taranjit S. Gujral,
  • Raymond S. Yeung

DOI
https://doi.org/10.34133/bmef.0022
Journal volume & issue
Vol. 4

Abstract

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In the era of personalized oncology, there have been accelerated efforts to develop clinically relevant platforms to test drug sensitivities of individual cancers. An ideal assay will serve as a diagnostic companion to inform the oncologist of the various treatments that are sensitive and insensitive, thus improving outcome while minimizing unnecessary toxicities and costs. To date, no such platform exists for clinical use, but promising approaches are on the horizon that take advantage of improved techniques in creating human cancer models that encompass the entire tumor microenvironment, alongside technologies for assessing and analyzing tumor response. This review summarizes a number of current strategies that make use of intact human cancer tissues as organotypic cultures in drug sensitivity testing.