The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

Giovanni S. Offeddu; Cynthia Hajal; Colleen R. Foley; Zhengpeng Wan; Lina Ibrahim; Mark F. Coughlin; Roger D. Kamm

doi:10.1038/s42003-021-01774-2

Communications Biology (Feb 2021)

The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

Giovanni S. Offeddu,
Cynthia Hajal,
Colleen R. Foley,
Zhengpeng Wan,
Lina Ibrahim,
Mark F. Coughlin,
Roger D. Kamm

Affiliations

Giovanni S. Offeddu: Department of Biological Engineering, Massachusetts Institute of Technology
Cynthia Hajal: Department of Mechanical Engineering, Massachusetts Institute of Technology
Colleen R. Foley: Department of Biological Engineering, Massachusetts Institute of Technology
Zhengpeng Wan: Department of Biological Engineering, Massachusetts Institute of Technology
Lina Ibrahim: Department of Mechanical Engineering, Massachusetts Institute of Technology
Mark F. Coughlin: Department of Biological Engineering, Massachusetts Institute of Technology
Roger D. Kamm: Department of Biological Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s42003-021-01774-2
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 10

Abstract

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Offeddu et al. employ a microfluidic vascular model to study the effects of selective removal of glycocalyx components from cancer cells. They find that cancer-associated hyaluronic acid and CD44 mediate firm adhesion to endothelial cells and extravasation during metastasis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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