Common Matrix Metalloproteinases (Mmp-8, -9, -25, and -26) Cannot Explain Dentigerous Cyst Expansion

Juho Suojanen; Niko Lehtonen; Esa Färkkilä; Jarkko Hietanen; Olli Teronen; Timo Sorsa; Jaana Hagström

doi:10.7860/JCDR/2014/9221.4899

Journal of Clinical and Diagnostic Research (Sep 2014)

Common Matrix Metalloproteinases (Mmp-8, -9, -25, and -26) Cannot Explain Dentigerous Cyst Expansion

Juho Suojanen,
Niko Lehtonen,
Esa Färkkilä,
Jarkko Hietanen,
Olli Teronen,
Timo Sorsa,
Jaana Hagström

Affiliations

Juho Suojanen: Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland.
Niko Lehtonen: Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland.
Esa Färkkilä: Faculty, Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland.
Jarkko Hietanen: Faculty, Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland and HUSLAB.
Olli Teronen: Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland.
Timo Sorsa: Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland and Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Jaana Hagström: Faculty, Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland and HUSLAB and Department of Pathology, at the Haartman Institute and HUSLAB, Helsinki University Central Hospital, Finland.

DOI: https://doi.org/10.7860/JCDR/2014/9221.4899
Journal volume & issue: Vol. 8, no. 9
pp. ZC82 – ZC85

Abstract

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Objective: Mechanisms of the dentigerous cyst formation from the normal eruption follicle is unknown but disturbances in the proteolytic activity have been suspected, since the growth of these cysts is accompanied by local bone destruction. The aim of the present study was to evaluate the expression of matrix metalloproteinases (MMP) in human dental dentigerous cysts and healthy dental follicles. Materials and Methods: We studied 10 patients with dentigerous cysts and 10 healthy dental follicles from the lower jaw in respect to their immunoexpression of MMPs -8, -9, -25, and -26 and tissue inhibitor of metalloproteinases -1 (TIMP-1). Results: MMP-8 was expressed slightly more in cyst epithelium than in odontogenic epithelium of healthy controls dental follicle but the difference lacked statistical difference. Other MMPs and TIMP-1 did not differ regarding the studied specimens. Conclusion: Differences in MMP expression cannot solely explain the cyst expansion suggesting the potential involvement of other osteolytic mechanisms.

Published in Journal of Clinical and Diagnostic Research

ISSN: 2249-782X (Print); 0973-709X (Online)
Publisher: JCDR Research and Publications Private Limited
Country of publisher: India
LCC subjects: Medicine
Website: https://www.jcdr.net/

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