Role of a novel mouse mutant of the Galnt2tm1Lat/tm1Lat gene in otitis media

Weijun Ma; Heng Li; Juan Hu; Ying Gao; Hui Lv; Xiaotong Zhang; Qing Zhang; Min Xu; Ying Cheng

doi:10.3389/fneur.2022.1054704

Frontiers in Neurology (Feb 2023)

Role of a novel mouse mutant of the Galnt2tm1Lat/tm1Lat gene in otitis media

Weijun Ma,
Heng Li,
Juan Hu,
Ying Gao,
Hui Lv,
Xiaotong Zhang,
Qing Zhang,
Min Xu,
Ying Cheng

Affiliations

Weijun Ma: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Heng Li: Department of Otorhinolaryngology, Shiquan County Hospital, Ankang, Shaanxi, China
Juan Hu: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ying Gao: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Hui Lv: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Xiaotong Zhang: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Qing Zhang: Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
Min Xu: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
Ying Cheng: Department of Otolaryngology-Head and Neck Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China

DOI: https://doi.org/10.3389/fneur.2022.1054704
Journal volume & issue: Vol. 13

Abstract

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Genetic susceptibility is one of the most important causes of otitis media (OM). Mutant Galnt2 homozygote (Galnt2tm1Lat/tm1Lat) mimics human otitis media in comparable pathology and causes hearing loss. Otitis media is characterized by effusion and dysregulated mucosa proliferation and capillary expansion in the middle ear cavity, which is associated with hearing loss. The mucociliary dysfunction could be seen in the middle ear cavity (MEC) in a patient harboring the disease that develops in severity with age by a scanning electron microscope. Tumor necrosis factor alpha (TNF-α), transforming growth factor-beta 1 (TGF-β1), Muc5ac, and Muc5b upregulate the expression in the middle ear, which correlates with inflammation, craniofacial development, and mucin secretion. The mouse model with a mutation in the Galnt2 (Galnt2tm1Lat/tm1Lat) was explored in this study as a novel model of human otitis media.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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