<em>Buddleja officinalis Maximowicz</em> Extract Inhibits Lipid Accumulation on Adipocyte Differentiation in 3T3-L1 Cells and High-Fat Mice

Abstract

Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. In this study, we elucidated that <em>Buddleja officinalis Maximowicz </em>extract significantly inhibited lipid accumulation during 3T3-L1 adipocyte differentiation. Furthermore, <em>Buddleja officinalis Maximowicz </em>extract reduced the body weight gain induced through feeding a high-fat diet to C57BL/6 mice. The treatment of <em>Buddleja officinalis Maximowicz </em>extract significantly reduced the adipose tissue weight to 2.7/100 g of body weight in high-fat mice. When their adipose tissue morphology was investigated for histochemical staining, the distribution of cell size in the high-fat diet groups was hypertrophied compared with those from <em>Buddleja officinalis Maximowicz </em>extract-treated mice. In addition, in <em>Buddleja officinalis Maximowicz </em>extract-treated mice, a significant reduction of serum triglyceride and T-cholesterol was observed at to 21% and 17%, respectively. The discovery of bioactive compounds from diet or dietary supplementation is one of possible ways to control obesity and to prevent or reduce the risks of various obesity-related diseases. These results support that <em>Buddleja officinalis Maximowicz</em> extract is expected to create the therapeutic interest with respect to the treatment of obesity.

Keywords

• anti-obesity
• lipid inhibition
• adipocyte differentiation
• &lt;em&gt;Buddleja officinalis Maximowicz&lt;/em&gt; extract