A recapitulation of the polycystic ovarian disorder in adult women and the risk of disease associated with the polycystic ovarian disorder

Abstract

Polycystic ovarian disease is a highly prevalent hormonal, metabolic, and reproductive condition (PCOD). The overall health load of PCOD is delicate in individual females with the situation who are in the generative phase due to their increased risk and frequency of prediabetes, diabetes, and additional comorbidities such as obstructive endometrial cancer and mental health disorders, and sleep apnea. However, less information is available that how PCOD affects older women's long-term health. In this review, we wanted to provide a rationalized overview of the longstanding health effects of PCOD and their clinical implications in premenopause and post-menopause. The phenotype of PCOD improves with age, and very little information that is currently available indicates that the cardiometabolic profile of PCOD-positive women does not worsen after menopause. Therefore, based on their possibility during reproductive years, the risk of cardiovascular disorder in older women with PCOD seems to be lower than previously expected and no different from that of older women without PCOD. Due to confusing variables and a paucity of long-term cohort studies, it is challenging to assess the real danger in aged women with PCOD for other comorbidities such as obesity, mood disorders, and endometrial cancer.

Keywords

• Polycystic ovarian disease
• Cancer
• Dyslipidaemia
• Hypertension
• Diabetes mellitus, Obesity