Precardiac organoids form two heart fields via Bmp/Wnt signaling

Peter Andersen; Emmanouil Tampakakis; Dennisse V. Jimenez; Suraj Kannan; Matthew Miyamoto; Hye Kyung Shin; Amir Saberi; Sean Murphy; Edrick Sulistio; Stephen P. Chelko; Chulan Kwon

doi:10.1038/s41467-018-05604-8

Nature Communications (Aug 2018)

Precardiac organoids form two heart fields via Bmp/Wnt signaling

Peter Andersen,
Emmanouil Tampakakis,
Dennisse V. Jimenez,
Suraj Kannan,
Matthew Miyamoto,
Hye Kyung Shin,
Amir Saberi,
Sean Murphy,
Edrick Sulistio,
Stephen P. Chelko,
Chulan Kwon

Affiliations

Peter Andersen: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Emmanouil Tampakakis: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Dennisse V. Jimenez: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Suraj Kannan: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Matthew Miyamoto: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Hye Kyung Shin: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Amir Saberi: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Sean Murphy: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Edrick Sulistio: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Stephen P. Chelko: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
Chulan Kwon: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05604-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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The heart arises from distinct progenitor cells of both the first and second heart fields (FHF and SHF). Here, the authors generated precardiac organoids from mouse and human pluripotent cells and show that FHF and SHF cells form similarly to their in vivo counterparts in response to BMP and Wnt signalling, respectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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