Pulsed Cavitational Ultrasound Softening

Olivier Villemain, MD; Justine Robin, MS; Alain Bel, MD; Wojciech Kwiecinski, PhD; Patrick Bruneval, MD; Bastien Arnal, PhD; Mathieu Rémond, PhD; Mickael Tanter, PhD; Emmanuel Messas, MD, PhD; Mathieu Pernot, PhD

doi:10.1016/j.jacbts.2017.03.012

JACC: Basic to Translational Science (Aug 2017)

Pulsed Cavitational Ultrasound Softening

Olivier Villemain, MD,
Justine Robin, MS,
Alain Bel, MD,
Wojciech Kwiecinski, PhD,
Patrick Bruneval, MD,
Bastien Arnal, PhD,
Mathieu Rémond, PhD,
Mickael Tanter, PhD,
Emmanuel Messas, MD, PhD,
Mathieu Pernot, PhD

Affiliations

Olivier Villemain, MD: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France
Justine Robin, MS: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France
Alain Bel, MD: Hôpital Européen Georges Pompidou, Cardiovascular Surgery, Université Paris Descartes, Laboratoire de Recherche Biochirurgical, Paris, France
Wojciech Kwiecinski, PhD: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France
Patrick Bruneval, MD: Hôpital Européen Georges Pompidou, Université Paris Descartes, Department of Pathology, Paris, France
Bastien Arnal, PhD: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France
Mathieu Rémond, PhD: Cardiawave SAS, Paris, France
Mickael Tanter, PhD: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France
Emmanuel Messas, MD, PhD: Hôpital Européen Georges Pompidou, Université Paris Descartes, Cardio-Vascular Departement, UMR 970, Paris, France
Mathieu Pernot, PhD: Institut Langevin, Ecole Supérieure de Physique Chimie Industrielles de Paris, Centre National de la Recherche Scientifique, Inserm U979, PSL Research University, Paris, France

DOI: https://doi.org/10.1016/j.jacbts.2017.03.012
Journal volume & issue: Vol. 2, no. 4
pp. 372 – 383

Abstract

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The authors propose a novel noninvasive therapeutic approach for degenerative calcified bioprosthetic heart valves based on pulsed cavitational ultrasound (PCU) to improve the valvular function by remotely softening calcified stiff cusps. This study aims to demonstrate both in vivo, using an ovine model with implanted human calcified bioprosthesis, and in vitro that PCU can significantly improve the bioprosthesis function. A 50% decrease of the transvalvular gradient was found, demonstrating a strong improvement of the valve opening function. This new noninvasive approach has the potential to improve the outcomes of patients with severe bioprosthesis stenosis.

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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