Nature Communications (Dec 2018)

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

  • Zhicheng Zeng,
  • Yuling Li,
  • Yangjian Pan,
  • Xiaoliang Lan,
  • Fuyao Song,
  • Jingbo Sun,
  • Kun Zhou,
  • Xiaolong Liu,
  • Xiaoli Ren,
  • Feifei Wang,
  • Jinlong Hu,
  • Xiaohui Zhu,
  • Wei Yang,
  • Wenting Liao,
  • Guoxin Li,
  • Yanqing Ding,
  • Li Liang

DOI
https://doi.org/10.1038/s41467-018-07810-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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The mechanisms underlying pre-metastatic niche formation by cancer derived exosomes is unclear. Here they show that colorectal cancer (CRC) derived exosomal miR-25-3p promotes vascular leakiness and angiogenesis, CRC metastasis, and is upregulated in CRC pateints with metastasis, and suggest miR-25-3p as a biomarker for CRC metastasis.