Saudi Journal of Kidney Diseases and Transplantation (Dec 2023)

Baclofen Toxicity in a Patient with End-stage Renal Disease on Maintenance Dialysis

  • Samar Ahmed,
  • Mahmoud Kharrat,
  • Hesham Salah,
  • Fouad Shearyia,
  • Reem Alrimawi,
  • Azizah Makhsoom,
  • Sahal Al sharif,
  • Rozana Alyami,
  • Faissal Shaheen

DOI
https://doi.org/10.4103/1319-2442.391005
Journal volume & issue
Vol. 34, no. 1
pp. 84 – 86

Abstract

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Baclofen is a β-(p-chlorophenyl) derivative of the neurotransmitter y-aminobutyrio acid (GABA). This centrally-acting GABA agonist is prescribed as therapy for spasticity in the spinal cord region. The drug is predominantly excreted by the kidney, thus making patients with kidney disease susceptible to side effects. We report on a patient with end-stage renal disease who developed baclofen toxicity, which was successfully treated with intense hemodialysis.