Frontiers in Oncology (May 2022)
Robot-Assisted, Laparoscopic, and Open Radical Cystectomy: Pre-Operative Data of 1400 Patients From The Italian Radical Cystectomy Registry
- Gian Maria Busetto,
- Daniele D’Agostino,
- Michele Colicchia,
- Katie Palmer,
- Walter Artibani,
- Alessandro Antonelli,
- Lorenzo Bianchi,
- Aldo Bocciardi,
- Eugenio Brunocilla,
- Marco Carini,
- Giuseppe Carrieri,
- Luigi Cormio,
- Ugo Giovanni Falagario,
- Ettore De Berardinis,
- Alessandro Sciarra,
- Costantino Leonardo,
- Francesco Del Giudice,
- Martina Maggi,
- Ottavio de Cobelli,
- Matteo Ferro,
- Gennaro Musi,
- Amelio Ercolino,
- Fabrizio Di Maida,
- Andrea Gallina,
- Carlo Introini,
- Ettore Mearini,
- Giovanni Cochetti,
- Andrea Minervini,
- Francesco Montorsi,
- Riccardo Schiavina,
- Sergio Serni,
- Claudio Simeone,
- Paolo Parma,
- Armando Serao,
- Mario Salvatore Mangano,
- Giorgio Pomara,
- Pasquale Ditonno,
- Alchiede Simonato,
- Daniele Romagnoli,
- Alessandro Crestani,
- Angelo Porreca
Affiliations
- Gian Maria Busetto
- Department of Urology and Renal Transplantation, University of Foggia, Policlinico Riuniti, Foggia, Italy
- Daniele D’Agostino
- Department of Urology, Villa Salus Clinic, Mestre, Italy
- Michele Colicchia
- Department of Urology, Policlinico Abano Terme, Abano Terme, Italy
- Katie Palmer
- Department of Internal Medicine and Geriatrics, University Cattolica del Sacro Cuore, Rome, Italy
- Walter Artibani
- Department of Urology, Policlinico Abano Terme, Abano Terme, Italy
- Alessandro Antonelli
- Department of Urology, Azienda Ospedaliera Universitaria Integrata (A.O.U.I.), Verona, Italy
- Lorenzo Bianchi
- Department of Urology, University of Bologna, Bologna, Italy
- Aldo Bocciardi
- Department of Urology, Niguarda Hospital, Milano, Italy
- Eugenio Brunocilla
- Department of Urology, University of Bologna, Bologna, Italy
- Marco Carini
- Department of Urology, University of Florence, Florence, Italy
- Giuseppe Carrieri
- Department of Urology, Villa Salus Clinic, Mestre, Italy
- Luigi Cormio
- Department of Urology, Villa Salus Clinic, Mestre, Italy
- Ugo Giovanni Falagario
- Department of Urology, Villa Salus Clinic, Mestre, Italy
- Ettore De Berardinis
- Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy
- Alessandro Sciarra
- Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy
- Costantino Leonardo
- Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy
- Francesco Del Giudice
- Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy
- Martina Maggi
- Department of Maternal-Child and Urological Sciences, Sapienza Rome University, Policlinico Umberto I, Rome, Italy
- Ottavio de Cobelli
- 0Department of Urology, European Institute of Oncology (IEO), IRCCS, Milan, Italy
- Matteo Ferro
- 0Department of Urology, European Institute of Oncology (IEO), IRCCS, Milan, Italy
- Gennaro Musi
- 0Department of Urology, European Institute of Oncology (IEO), IRCCS, Milan, Italy
- Amelio Ercolino
- Department of Urology, University of Bologna, Bologna, Italy
- Fabrizio Di Maida
- Department of Urology, University of Florence, Florence, Italy
- Andrea Gallina
- 1Department of Urology, San Raffaele Hospital and Scientific Institute, Milan, Italy
- Carlo Introini
- 2Department of Urology, Galliera Hospital, Genoa, Italy
- Ettore Mearini
- 3Department of Urology, University of Perugia, Perugia, Italy
- Giovanni Cochetti
- 3Department of Urology, University of Perugia, Perugia, Italy
- Andrea Minervini
- Department of Urology, University of Florence, Florence, Italy
- Francesco Montorsi
- 1Department of Urology, San Raffaele Hospital and Scientific Institute, Milan, Italy
- Riccardo Schiavina
- Department of Urology, University of Bologna, Bologna, Italy
- Sergio Serni
- Department of Urology, University of Florence, Florence, Italy
- Claudio Simeone
- 4Department of Urology, University of Brescia, Brescia, Italy
- Paolo Parma
- 5Department of Urology, Azienda Socio Sanitaria Territoriale (ASST) Mantova, Mantova, Italy
- Armando Serao
- 6Department of Urology, Azienda Ospedaliera di Alessandria, Alessandria, Italy
- Mario Salvatore Mangano
- 7Department of Urology, Ca’ Foncello Hospital, Treviso, Italy
- Giorgio Pomara
- 8Department of Urology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy
- Pasquale Ditonno
- 9Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy
- Alchiede Simonato
- 0Department of Surgical, Oncological and Oral Sciences, Section of Urology, University of Palermo, Palermo, Italy
- Daniele Romagnoli
- Department of Urology, Policlinico Abano Terme, Abano Terme, Italy
- Alessandro Crestani
- 1Oncological Urology, Veneto Institute of Oncology (IOV) – Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy
- Angelo Porreca
- 1Oncological Urology, Veneto Institute of Oncology (IOV) – Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy
- DOI
- https://doi.org/10.3389/fonc.2022.895460
- Journal volume & issue
-
Vol. 12
Abstract
IntroductionThe Italian Radical Cystectomy Registry (RIC) is an observational prospective study aiming to understand clinical variables and patient characteristics associated with short- and long-term outcomes among bladder cancer (BC) patients undergoing radical cystectomy (RC). Moreover, it compares the effectiveness of three RC techniques - open, robotic, and laparoscopic.MethodsFrom 2017 to 2020, 1400 patients were enrolled at one of the 28 centers across Italy. Patient characteristics, as well as preoperative, postoperative, and follow-up (3, 6, 12, and 24 months) clinical variables and outcomes were collected.ResultsPreoperatively, it was found that patients undergoing robotic procedures were younger (p<.001) and more likely to have undergone preoperative neoadjuvant chemotherapy (p<.001) and BCG instillation (p<.001). Hypertension was the most common comorbidity among all patients (55%), and overall, patients undergoing open and laparoscopic RC had a higher Charlson Comorbidities Index (CCI) compared to robotic RC (p<.001). Finally, laparoscopic patients had a lower G-stage classification (p=.003) and open patients had a higher ASA score (p<.001).ConclusionThe present study summarizes the characteristic of patients included in the RIC. Future results will provide invaluable information about outcomes among BC patients undergoing RC. This will inform physicians about the best techniques and course of care based on patient clinical factors and characteristics.
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