BIOLOGICAL ACTIVITY OF HYDROGENALIDES OF AMIDEZONE

Abstract

The biological activity of a number of N'-arylbenzenecarbоximidohydrazide hydrohalides in vitro against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Candida albicans and Aspergillus brasiliensis fungi, as well as anti-inflammatory and analgesic activities in vivo has been studied. N'-(4-nitrophenyl)benzenecarboximidohydrazide hydrochloride (3c) exhibits marked antimicrobial activity against St. aureus, 4-nitro-N'-phenylbenzenecarboximidohydrazide hydrochloride (3b) is effective against C. albicans and A. brasiliensis fungi. Acute toxicity of the obtained compounds for mice with intragastric administration was 1000 to 2000 mg/kg and intraperitoneal administration was 200 to 400 mg/kg. 4-nitro-N'-phenylbenzenecarboximidohydrazide hydrochloride (3b) has anti-inflammatory and analgesic activities that do not exceed that of the reference preparations.

Keywords

• antifungal activity
• antimicrobial activity
• analgesic activity
• anti-inflammatory activity
• acute toxicity
• hydrohalides of n'-arylbenzenecarboximidohydrazides