Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy

Rebecca A. Ellwood; Luke Slade; Jonathan Lewis; Roberta Torregrossa; Surabhi Sudevan; Mathew Piasecki; Matthew Whiteman; Timothy Etheridge; Nathaniel J. Szewczyk

doi:10.1038/s42003-022-04212-z

Communications Biology (Nov 2022)

Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy

Rebecca A. Ellwood,
Luke Slade,
Jonathan Lewis,
Roberta Torregrossa,
Surabhi Sudevan,
Mathew Piasecki,
Matthew Whiteman,
Timothy Etheridge,
Nathaniel J. Szewczyk

Affiliations

Rebecca A. Ellwood: MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham & National Institute for Health Research Nottingham Biomedical Research Centre
Luke Slade: Sport and Health Sciences, University of Exeter
Jonathan Lewis: MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham & National Institute for Health Research Nottingham Biomedical Research Centre
Roberta Torregrossa: University of Exeter Medical School, University of Exeter
Surabhi Sudevan: MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham & National Institute for Health Research Nottingham Biomedical Research Centre
Mathew Piasecki: MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham & National Institute for Health Research Nottingham Biomedical Research Centre
Matthew Whiteman: University of Exeter Medical School, University of Exeter
Timothy Etheridge: Sport and Health Sciences, University of Exeter
Nathaniel J. Szewczyk: MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham & National Institute for Health Research Nottingham Biomedical Research Centre

DOI: https://doi.org/10.1038/s42003-022-04212-z
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 12

Abstract

Read online

A C. elegans model of Duchenne muscular dystrophy reveals a potential role for disrupted sulfur metabolism in the disease and thus the therapeutic potential of sulfur amino acid supplementation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal