Frontiers in Nutrition (Oct 2024)

Vitamin C intake and osteoarthritis: findings of NHANES 2003–2018 and Mendelian randomization study

  • Hongjie Zhang,
  • Hongjie Zhang,
  • Hongjie Zhang,
  • Xuan Jiang,
  • Xuan Jiang,
  • Lei Bai,
  • Jiahui Chen,
  • Wei Luo,
  • Jianxiong Ma,
  • Xinlong Ma

DOI
https://doi.org/10.3389/fnut.2024.1409578
Journal volume & issue
Vol. 11

Abstract

Read online

BackgroundThe role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between vitamin C intake and OA.MethodsClinical information on participants during NHANES 2003–2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling. In MR analyses, three methods were used to explore the causality of vitamin C intake with OA. Sensitivity analysis to verify the stability of the MR study.ResultsThe cross-sectional study included a total of 31,527 participants, categorizing them into low (<30.2 mg), medium (30.2–93.0 mg) and high (>93.0 mg) level groups based on their vitamin C intake levels. Logistic regression models showed that vitamin C intake was not associated with OA risk (p > 0.05). Inverse-variance weighted (IVW) method of MR study showed no causality between vitamin C intake and OA (OR = 0.993, 95% CI: 0.901 ~ 1.095, p = 0.882). Sensitivity analysis indicated that the MR study was reliable.ConclusionOur cross-sectional and MR studies showed that vitamin C intake was not associated with OA risk. More researches are needed in the future to investigate the link between vitamin C and OA.

Keywords