The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance

Abstract

Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3′ untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.

Keywords

• drug resistance
• cancer metabolism
• glutamine
• post-transcriptional regulation