Xin yixue (Feb 2024)

Correlation analysis between hypertension，abnormal blood glucose and lipid metabolism and the site and frequency of gout attack

  • Li Shuwei, Zhu Yong, Lu Xueling

DOI
https://doi.org/10.3969/j.issn.0253-9802.2024.02.010
Journal volume & issue
Vol. 55, no. 2
pp. 127 – 131

Abstract

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Objective To analyze the correlation between hypertension，abnormal blood glucose and lipid metabolism and the site and frequency of gout attack. Methods Clinical data of 84 primary gout patients were collected. Gender，age，height，body weight，body mass index （BMI），complicated diseases，site and frequency of gout attack were recorded. The differences of clinical parameters at different sites of gout attack were compared. The differences of frequency of gout attack in patients complicated with diabetes mellitus，hypertension and hyperlipidemia at different time points were also compared. The relationship between age and BMI，and frequency of gout attack was assessed by Spearman’s rank correlation analysis. Results Among 84 patients with primary gout，82 patients were male and 2 female，aged （37.95±10.16） years on average，with a mean height of 170 （165，175） cm，mean weight of 76 （70，83） kg，mean BMI of 26.5 （24.6，29.3） kg/m2. Among them，7 patients （8%） were complicated with diabetes mellitus，18 cases （21%） of hypertension and 16 cases （19%） of hyperlipidemia. the most common site of gout attack was the lower limb，especially the metatarsophalangeal joint （38.10%） and knee joint （35.71%）. The frequency of gout attack within 1，6 and 12 months in gout patients complicated with hypertension was higher compared with that in those without hypertension （all P<0.05）. The frequency of gout attack in gout patients complicated with hypertension was increased over time （all P < 0.05/6 between any two consecutive time points）. BMI of gout patients was positively correlated with 1-year cumulative frequency of gout attack （rs=0.28，P<0.05）. Conclusions The frequency of gout attack in patients complicated with hypertension is higher compared with that of their counterparts without hypertension. The frequency of gout attack is increased over time. Extensive attention should be diverted to blood pressure and BMI in gout patients，thereby reducing the frequency of gout attack.

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