Frontiers in Neurology (Jun 2023)

The continuous performance test aids the diagnosis of post-stroke cognitive impairment in patients with right hemisphere damage

  • XiuLi Li,
  • XiuLi Li,
  • FuBiao Huang,
  • FuBiao Huang,
  • TieJun Guo,
  • TieJun Guo,
  • MengChen Feng,
  • MengChen Feng,
  • Shan Li,
  • Shan Li

DOI
https://doi.org/10.3389/fneur.2023.1173004
Journal volume & issue
Vol. 14

Abstract

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PurposeThe purpose of the study was to investigate the time course difference of relative changes in oxygenated hemoglobin (Oxy-Hb) concentration in the prefrontal cortex (PFC) between controls and patients with post-stroke cognitive impairment (PSCI) who had right hemisphere damage (RHD) using the continuous performance test (CPT) and functional near-infrared spectroscopy (fNIRS) technology. The study aimed to evaluate the feasibility of CPT in the diagnosis and evaluation of PSCI with RHD.MethodsA total of 16 patients with RHD (RHD group) and 32 normal subjects (control group) were recruited. The Montreal Cognitive Assessment Scale was used to assess post-stroke cognitive impairment. The CPT and fNIRS were employed to investigate task-related changes in Oxy-Hb levels.ResultsThe RHD group showed significantly lower accuracy and hit rates than the control group; however, the average reaction time was significantly longer in the former. Although the two groups showed no statistically significant difference in terms of left and right PFC integral values, the mean values were greater in the RHD group. The centroid value of the right PFC was significantly higher in the RHD group than in the control group. The time course of Oxy-Hb concentrations in the PFC differed between the two groups. In the RHD group, neural compensation was observed in both prefrontal lobes; however, the rate of compensation was slower on the affected side.ConclusionThe CPT may be helpful in the clinical diagnosis of PSCI with RHD. It may therefore be used to evaluate the effectiveness of cognitive interventions.

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