Nature Communications (Sep 2019)
Dynamic changes of muscle insulin sensitivity after metabolic surgery
- Sofiya Gancheva,
- Meriem Ouni,
- Tomas Jelenik,
- Chrysi Koliaki,
- Julia Szendroedi,
- Frederico G. S. Toledo,
- Daniel F. Markgraf,
- Dominik H. Pesta,
- Lucia Mastrototaro,
- Elisabetta De Filippo,
- Christian Herder,
- Markus Jähnert,
- Jürgen Weiss,
- Klaus Strassburger,
- Matthias Schlensak,
- Annette Schürmann,
- Michael Roden
Affiliations
- Sofiya Gancheva
- Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University
- Meriem Ouni
- German Center for Diabetes Research (DZD e.V.)
- Tomas Jelenik
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University
- Chrysi Koliaki
- Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University
- Julia Szendroedi
- Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University
- Frederico G. S. Toledo
- Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine
- Daniel F. Markgraf
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University
- Dominik H. Pesta
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University
- Lucia Mastrototaro
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University
- Elisabetta De Filippo
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University
- Christian Herder
- Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University
- Markus Jähnert
- German Center for Diabetes Research (DZD e.V.)
- Jürgen Weiss
- German Center for Diabetes Research (DZD e.V.)
- Klaus Strassburger
- German Center for Diabetes Research (DZD e.V.)
- Matthias Schlensak
- General Surgery Department, Schön Clinics
- Annette Schürmann
- German Center for Diabetes Research (DZD e.V.)
- Michael Roden
- Division of Endocrinology and Diabetology, Medical Faculty, Heinrich-Heine University
- DOI
- https://doi.org/10.1038/s41467-019-12081-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Surgical weight-loss interventions improve insulin sensitivity via incompletely understood mechanisms. Here the authors assess skeletal muscle epigenetic changes in individuals with obesity following metabolic surgery and compare them with data from individuals without obesity.
