Current Chemistry Letters (Jan 2023)

Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives

  • V. B. R. K. Krishnan,
  • Santha Kumari Merugu,
  • V. Siva Rama Krishna Reddy,
  • Hari Babu Bollikolla

DOI
https://doi.org/10.5267/j.ccl.2022.10.001
Journal volume & issue
Vol. 12, no. 1
pp. 17 – 26

Abstract

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Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.