Communications Biology (Sep 2021)
Genetic variants associated with platelet count are predictive of human disease and physiological markers
- Evgenia Mikaelsdottir,
- Gudmar Thorleifsson,
- Lilja Stefansdottir,
- Gisli Halldorsson,
- Jon K. Sigurdsson,
- Sigrun H. Lund,
- Vinicius Tragante,
- Pall Melsted,
- Solvi Rognvaldsson,
- Kristjan Norland,
- Anna Helgadottir,
- Magnus K. Magnusson,
- Gunnar B. Ragnarsson,
- Sigurdur Y. Kristinsson,
- Sigrun Reykdal,
- Brynjar Vidarsson,
- Ingibjorg J. Gudmundsdottir,
- Isleifur Olafsson,
- Pall T. Onundarson,
- Olof Sigurdardottir,
- Emil L. Sigurdsson,
- Gerdur Grondal,
- Arni J. Geirsson,
- Gudmundur Geirsson,
- Julius Gudmundsson,
- Hilma Holm,
- Saedis Saevarsdottir,
- Ingileif Jonsdottir,
- Gudmundur Thorgeirsson,
- Daniel F. Gudbjartsson,
- Unnur Thorsteinsdottir,
- Thorunn Rafnar,
- Kari Stefansson
Affiliations
- Evgenia Mikaelsdottir
- deCODE Genetics/Amgen
- Gudmar Thorleifsson
- deCODE Genetics/Amgen
- Lilja Stefansdottir
- deCODE Genetics/Amgen
- Gisli Halldorsson
- deCODE Genetics/Amgen
- Jon K. Sigurdsson
- deCODE Genetics/Amgen
- Sigrun H. Lund
- deCODE Genetics/Amgen
- Vinicius Tragante
- deCODE Genetics/Amgen
- Pall Melsted
- deCODE Genetics/Amgen
- Solvi Rognvaldsson
- deCODE Genetics/Amgen
- Kristjan Norland
- deCODE Genetics/Amgen
- Anna Helgadottir
- deCODE Genetics/Amgen
- Magnus K. Magnusson
- deCODE Genetics/Amgen
- Gunnar B. Ragnarsson
- Department of Oncology, Landspitali-University Hospital
- Sigurdur Y. Kristinsson
- Faculty of Medicine, University of Iceland
- Sigrun Reykdal
- Department of Hematology, Landspitali-University Hospital
- Brynjar Vidarsson
- Department of Hematology, Landspitali-University Hospital
- Ingibjorg J. Gudmundsdottir
- Department of Cardiology, Landspitali-University Hospital
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali-University Hospital
- Pall T. Onundarson
- Faculty of Medicine, University of Iceland
- Olof Sigurdardottir
- Department of Clinical Biochemistry, Akureyri Hospital
- Emil L. Sigurdsson
- Development Centre for the Primary Care
- Gerdur Grondal
- Department of Rheumatology, Landspitali-University Hospital
- Arni J. Geirsson
- Department of Rheumatology, Landspitali-University Hospital
- Gudmundur Geirsson
- Department of Urology, Landspitali-University Hospital
- Julius Gudmundsson
- deCODE Genetics/Amgen
- Hilma Holm
- deCODE Genetics/Amgen
- Saedis Saevarsdottir
- deCODE Genetics/Amgen
- Ingileif Jonsdottir
- deCODE Genetics/Amgen
- Gudmundur Thorgeirsson
- deCODE Genetics/Amgen
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen
- Thorunn Rafnar
- deCODE Genetics/Amgen
- Kari Stefansson
- deCODE Genetics/Amgen
- DOI
- https://doi.org/10.1038/s42003-021-02642-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.
