Daily oscillations of neuronal membrane capacitance

Daniel Severin; Cristián Moreno; Trinh Tran; Christian Wesselborg; Sofia Shirley; Altagracia Contreras; Alfredo Kirkwood; Jorge Golowasch

Cell Reports (Oct 2024)

Daily oscillations of neuronal membrane capacitance

Daniel Severin,
Cristián Moreno,
Trinh Tran,
Christian Wesselborg,
Sofia Shirley,
Altagracia Contreras,
Alfredo Kirkwood,
Jorge Golowasch

Affiliations

Daniel Severin: Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Rm. 350 Dunning Hall, 3400 N. Charles St., Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Cristián Moreno: Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Rm. 350 Dunning Hall, 3400 N. Charles St., Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Trinh Tran: Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Rm. 350 Dunning Hall, 3400 N. Charles St., Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Christian Wesselborg: Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Sofia Shirley: Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Altagracia Contreras: Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA
Alfredo Kirkwood: Johns Hopkins Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Rm. 350 Dunning Hall, 3400 N. Charles St., Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA; Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA; Corresponding author
Jorge Golowasch: Department of Biological Sciences, New Jersey Institute of Technology, Newark, NJ 07102, USA; Corresponding author

Journal volume & issue: Vol. 43, no. 10
p. 114744

Abstract

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Summary: Capacitance of biological membranes is determined by the properties of the lipid portion of the membrane as well as the morphological features of a cell. In neurons, membrane capacitance is a determining factor of synaptic integration, action potential propagation speed, and firing frequency due to its direct effect on the membrane time constant. Besides slow changes associated with increased morphological complexity during postnatal maturation, neuronal membrane capacitance is considered a stable, non-regulated, and constant magnitude. Here we report that, in two excitatory neuronal cell types, pyramidal cells of the mouse primary visual cortex and granule cells of the hippocampus, the membrane capacitance significantly changes between the start and the end of a daily light-dark cycle. The changes are large, nearly 2-fold in magnitude in pyramidal cells, but are not observed in cortical parvalbumin-expressing inhibitory interneurons. Consistent with daily capacitance fluctuations, the time window for synaptic integration also changes in pyramidal cells.

CP: Neuroscience

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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