The protective role of vitamin C on tissue changes induced kidney toxicity in Rats

Abstract

Background: Although the use of pesticides to control agricultural pests are the most effective, but its harmful effects on the ecosystem that can't be ignored .Therefore, to survey the effect of Deltamethrine with widely used and vitamin C with antioxidant role in protective of it, were studied. Methods: 63 rats (Wistar) weighing 200 ± 15 g were divided into 9 groups. groups include control (no treatment), sham 1 (received water), sham 2 were injected ( 20 mg / kg/b.wt) Vitamin C, 3 treatment groups, respectively (2.5, 5 and 10) mg/kg/b.wt of deltamethrin and 3 groups treated with the same doses of Deltamethrin + vitamin C (20mg / kg/b.wt) injected intraperitoneal within 14 days. After 14 dayst, Rat's kidneys were separated, fixed in formalin (10%), slide prepared, staining and tissue change were studied with L.M. Obtain data were analyzed and compared by using SPSS, ANOVA and Dankan test (P< 0.05). Results:The most of changes were respectively in diameter of Bowman’s capsule, glumerules and collecting tube in treatment groups. No significant deference was in all groups. The obtained micrographs confirmed the above results and induction of glumerules, cell destruction and tissue full of blood were observed. Conclusion: According to obtained results, the effect of Deltamethrine on kidney tissue, is low and Vitamin C with usage dose, didn’t protective effect. So the more caution is recommended for using this pesticide Key words: Deltamethrine, Glumerules, Urinary tubes, Rat

Keywords

• key words: deltamethrine
• glumerules
• urinary tubes
• rat