Stem Cell Research (Jan 2019)

Derivation of iPSC lines from two patients with familial Alzheimer's disease from India

  • Ashaq H. Najar,
  • K.M. Sneha,
  • Aparna Ashok,
  • Swathy Babu,
  • Anand G. Subramaniam,
  • Ramkrishnan Kannan,
  • Biju Viswanath,
  • Meera Purushottam,
  • Mathew Varghese,
  • Suhel Parvez,
  • Mitradas M. Panicker,
  • Odity Mukherjee,
  • Sanjeev Jain

Journal volume & issue
Vol. 34

Abstract

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The current prevalence of diagnosable dementia in India is 1% of people over 60 years (~3.7 million people), but is estimated to increase significantly, as ~15% world's aged population (>65 years) would be resident here by 2020 (Shah et al., 2016). While several mutations that pose a familial risk have been identified, the ethnic background may influence disease susceptibility, clinical presentation and treatment response. In this study, we report a detailed characterization of two representative HiPSC lines from a well-characterized dementia cohort from India. Availability of these lines, and associated molecular and clinical information, would be useful in the detailed exploration of the genomic contribution(s) to AD.