Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery

Abstract

The possibility of vardenafil using for pharmacological preconditioning in surgery is studied. Experiment was carried out on Wistar rats. The influence of vardenafil on the survival of pedicled isolated skin flap and the state of the microvasculature in the ischemic skeletal muscle was defined in comparison with the effect of distant ischemic preconditioning. It was revealed that vardenafil improves survival of pedicled isolated skin flap and stimulates angiogenesis in the ischemic leg muscles of rat.

Keywords

• прекондиционирование
• варденафил
• ишемия
• неоангиогенез
• preconditioning
• vardenafil
• ischemia
• neoangiogenesis