Zinc is a potent and specific inhibitor of IFN-λ3 signalling

Scott A. Read; Kate S. O’Connor; Vijay Suppiah; Chantelle L. E. Ahlenstiel; Stephanie Obeid; Kristina M. Cook; Anthony Cunningham; Mark W. Douglas; Philip J. Hogg; David Booth; Jacob George; Golo Ahlenstiel

doi:10.1038/ncomms15245

Nature Communications (May 2017)

Zinc is a potent and specific inhibitor of IFN-λ3 signalling

Scott A. Read,
Kate S. O’Connor,
Vijay Suppiah,
Chantelle L. E. Ahlenstiel,
Stephanie Obeid,
Kristina M. Cook,
Anthony Cunningham,
Mark W. Douglas,
Philip J. Hogg,
David Booth,
Jacob George,
Golo Ahlenstiel

Affiliations

Scott A. Read: Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Kate S. O’Connor: Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Vijay Suppiah: School of Pharmacy and Medical Science, University of South Australia
Chantelle L. E. Ahlenstiel: The Kirby Institute for Infection and Immunity in Society, University of New South Wales
Stephanie Obeid: Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Kristina M. Cook: The Centenary Institute
Anthony Cunningham: Centre of Virus Research, Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Mark W. Douglas: Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Philip J. Hogg: National Health and Medical Research Council Clinical Trials Centre, University of Sydney
David Booth: Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Jacob George: Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital
Golo Ahlenstiel: Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead Hospital

DOI: https://doi.org/10.1038/ncomms15245
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal