Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis

Fei Kang; Li Xie; Tairan Qin; Yifan Miao; Youhou Kang; Toshimasa Takahashi; Tao Liang; Huanli Xie; Herbert Y. Gaisano

doi:10.1038/s41467-022-33986-3

Nature Communications (Oct 2022)

Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis

Fei Kang,
Li Xie,
Tairan Qin,
Yifan Miao,
Youhou Kang,
Toshimasa Takahashi,
Tao Liang,
Huanli Xie,
Herbert Y. Gaisano

Affiliations

Fei Kang: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Li Xie: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Tairan Qin: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Yifan Miao: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Youhou Kang: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Toshimasa Takahashi: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Tao Liang: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Huanli Xie: Department of Medicine, Temerty Faculty of Medicine, University of Toronto
Herbert Y. Gaisano: Department of Medicine, Temerty Faculty of Medicine, University of Toronto

DOI: https://doi.org/10.1038/s41467-022-33986-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Kang and colleagues find that plasma membrane flipping of Syntaxin-2 from inside (inhibitory) to outside (relief of inhibition) of pancreatic β-cells helps fine-tune insulin secretion. Increasing this flipping efficiency can alleviate the impaired insulin secretion in diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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