Nature Communications (Oct 2022)

Central role of Prominin-1 in lipid rafts during liver regeneration

  • Myeong-Suk Bahn,
  • Dong-Min Yu,
  • Myoungwoo Lee,
  • Sung-Je Jo,
  • Ji-Won Lee,
  • Ho-Chul Kim,
  • Hyun Lee,
  • Hong Lim Kim,
  • Arum Kim,
  • Jeong-Ho Hong,
  • Jun Seok Kim,
  • Seung-Hoi Koo,
  • Jae-Seon Lee,
  • Young-Gyu Ko

DOI
https://doi.org/10.1038/s41467-022-33969-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.