Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones

Abstract

The pace of life in the XXI century often leads to mental and physical fatigue, which can be neutralized by drugs, namely actoprotectors. Aim. To find compounds able to increase physical endurance among 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, which are promising in this regard. Methods and results. Actoprotective activity was tested on Wistar white rats by swimming test with the extra weight. It was found, that compounds, intragastrically administrated in 50 mg/kg, increased the duration of swimming in conditions of normothermia and hypothermia. Conclusion. Rats’ swimming duration compared with control has increased for compounds 1, 4 and 7 to 55.50%, 42.36% and 22.92% against 22.20% of «Mildronate». The leading compound was revealed, namely, 6-methyltetrazolo[1,5-c]quinazolin-5(6H)-one, which exceeded the activity of reference drug in the normothermia and hypothermia. And it has been established, that sulfur in the 5th position of tetrazolo[1,5-c]quinazoline is a key element in exhibiting the actoprotective activity.

Keywords

• 6-N-R-Tetrazolo[1
• 5-c]quinazolin-5(6H)-ones
• Normothermia
• Hypothermia