Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

Kevin P. Mouillesseaux; David S. Wiley; Lauren M. Saunders; Lyndsay A. Wylie; Erich J. Kushner; Diana C. Chong; Kathryn M. Citrin; Andrew T. Barber; Youngsook Park; Jun-Dae Kim; Leigh Ann Samsa; Jongmin Kim; Jiandong Liu; Suk-Won Jin; Victoria L. Bautch

doi:10.1038/ncomms13247

Nature Communications (Nov 2016)

Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

Kevin P. Mouillesseaux,
David S. Wiley,
Lauren M. Saunders,
Lyndsay A. Wylie,
Erich J. Kushner,
Diana C. Chong,
Kathryn M. Citrin,
Andrew T. Barber,
Youngsook Park,
Jun-Dae Kim,
Leigh Ann Samsa,
Jongmin Kim,
Jiandong Liu,
Suk-Won Jin,
Victoria L. Bautch

Affiliations

Kevin P. Mouillesseaux: Department of Biology, The University of North Carolina at Chapel Hill
David S. Wiley: Department of Biology, The University of North Carolina at Chapel Hill
Lauren M. Saunders: Department of Biology, The University of North Carolina at Chapel Hill
Lyndsay A. Wylie: Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill
Erich J. Kushner: Department of Biology, The University of North Carolina at Chapel Hill
Diana C. Chong: Curriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill
Kathryn M. Citrin: Department of Biology, The University of North Carolina at Chapel Hill
Andrew T. Barber: Department of Biology, The University of North Carolina at Chapel Hill
Youngsook Park: Department of Life Systems, Sookmyung Women’s University
Jun-Dae Kim: Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, School of Medicine, Yale University
Leigh Ann Samsa: Department of Pathology and Laboratory Animal Medicine, The University of North Carolina at Chapel Hill
Jongmin Kim: Department of Life Systems, Sookmyung Women’s University
Jiandong Liu: Department of Pathology and Laboratory Animal Medicine, The University of North Carolina at Chapel Hill
Suk-Won Jin: Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, School of Medicine, Yale University
Victoria L. Bautch: Department of Biology, The University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/ncomms13247
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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