Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells

Kazuki Sasaki; Mouhamad Al Moussawy; Khodor I. Abou-Daya; Camila Macedo; Amira Hosni-Ahmed; Silvia Liu; Mariam Juya; Alan F. Zahorchak; Diana M. Metes; Angus W. Thomson; Fadi G. Lakkis; Hossam A. Abdelsamed

doi:10.1038/s42003-022-03596-2

Communications Biology (Jun 2022)

Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells

Kazuki Sasaki,
Mouhamad Al Moussawy,
Khodor I. Abou-Daya,
Camila Macedo,
Amira Hosni-Ahmed,
Silvia Liu,
Mariam Juya,
Alan F. Zahorchak,
Diana M. Metes,
Angus W. Thomson,
Fadi G. Lakkis,
Hossam A. Abdelsamed

Affiliations

Kazuki Sasaki: Department of Surgery, University of Pittsburgh, School of Medicine
Mouhamad Al Moussawy: Department of Surgery, University of Pittsburgh, School of Medicine
Khodor I. Abou-Daya: Department of Surgery, University of Pittsburgh, School of Medicine
Camila Macedo: Department of Surgery, University of Pittsburgh, School of Medicine
Amira Hosni-Ahmed: Department of Chemistry, Division of Biochemistry, Faculty of Science, Fayoum University
Silvia Liu: Pittsburgh Liver Research Center, School of Medicine
Mariam Juya: Department of Surgery, University of Pittsburgh, School of Medicine
Alan F. Zahorchak: Department of Surgery, University of Pittsburgh, School of Medicine
Diana M. Metes: Department of Surgery, University of Pittsburgh, School of Medicine
Angus W. Thomson: Department of Surgery, University of Pittsburgh, School of Medicine
Fadi G. Lakkis: Department of Surgery, University of Pittsburgh, School of Medicine
Hossam A. Abdelsamed: Department of Surgery, University of Pittsburgh, School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03596-2
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

Read online

Human activated memory CD8 T cells develop a non-cytotoxic function and influence the fate of autologous naïve CD8 T cells where they acquire an activated/memory state and a hybrid state between naïve and activated memory.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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