Dynamics of fractalkine among Kharkiv residents with different body mass

Abstract

Background. When developing individual approaches to treating obesity and comorbid diseases, the presence and severity of inflammation in adipose tissue should be taken into account, as it significantly affects its metabolism and secretion. One of the markers of inflammatory activity in adipose tissue is the circulatory level of fractalkine in the blood. The purpose of the study was to assess fractalkine level among representatives of Ukrainian population — residents of Kharkiv, depending on their body mass index, degree and topography of deposition of adipose tissue. Materials and methods. The study included 250 adult residents of Kharkiv. Level of fractalkine in circulation was defined by immunoenzyme method. We have analyzed the correlation between fractalkine and body mass index, the presence and degree of abdominal obesity, contents of adipose tissue, insulin level and index of insulin resistance HOMA. Results. It was found that the determining factor regarding the uncontrolled accumulation of adipose tissue is increased level of fractalkine. The direct connection was established between fractalkine level and sensitivity of tissues to insulin. Conclusions. It was found that body fat mass parameter is more informative in relation to the level of fractalkine than body mass index parameter.

Keywords

• obesity
• overweight
• fractalkine