Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Michael A. Durante; Daniel A. Rodriguez; Stefan Kurtenbach; Jeffim N. Kuznetsov; Margaret I. Sanchez; Christina L. Decatur; Helen Snyder; Lynn G. Feun; Alan S. Livingstone; J. William Harbour

doi:10.1038/s41467-019-14256-1

Nature Communications (Jan 2020)

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Michael A. Durante,
Daniel A. Rodriguez,
Stefan Kurtenbach,
Jeffim N. Kuznetsov,
Margaret I. Sanchez,
Christina L. Decatur,
Helen Snyder,
Lynn G. Feun,
Alan S. Livingstone,
J. William Harbour

Affiliations

Michael A. Durante: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Daniel A. Rodriguez: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Stefan Kurtenbach: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Jeffim N. Kuznetsov: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Margaret I. Sanchez: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Christina L. Decatur: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine
Helen Snyder: Cell IDx Inc.
Lynn G. Feun: Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
Alan S. Livingstone: Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
J. William Harbour: Bascom Palmer Eye Institute, University of Miami Miller School of Medicine

DOI: https://doi.org/10.1038/s41467-019-14256-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

Uveal melanoma is highly metastatic and unresponsive to checkpoint immunotherapy. Here, the authors present single-cell transcriptomics of 59,915 cells in 8 primary and 3 metastatic samples, highlighting the diversity of the tumour microenvironment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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