Nature Communications (Nov 2022)
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas
Abstract
LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinomas.