TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Ying Qin; Qi Li; Wenbo Liang; Rongzhen Yan; Li Tong; Mutian Jia; Chunyuan Zhao; Wei Zhao

doi:10.1038/s41467-021-25033-4

Nature Communications (Aug 2021)

TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

Ying Qin,
Qi Li,
Wenbo Liang,
Rongzhen Yan,
Li Tong,
Mutian Jia,
Chunyuan Zhao,
Wei Zhao

Affiliations

Ying Qin: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Qi Li: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Wenbo Liang: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Rongzhen Yan: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Li Tong: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Mutian Jia: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Chunyuan Zhao: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University
Wei Zhao: Department of Pathogenic Biology and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University

DOI: https://doi.org/10.1038/s41467-021-25033-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Post-translational modifications are important regulators of NLRP3 inflammasome activity. Here the authors show that the E3 ligase TRIM28 can SUMOylate NLRP3, thereby limiting its proteasomal degradation and increasing NLRP3 inflammasome activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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