Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic
<i>Yersinia</i>

David Balderas; Erin Mettert; Hanh N. Lam; Rajdeep Banerjee; Tomas Gverzdys; Pablo Alvarez; Geetha Saarunya; Natasha Tanner; Adam Zoubedi; Yahan Wei; Patricia J. Kiley; Victoria Auerbuch

doi:10.1128/mBio.00633-21

mBio (Jun 2021)

Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic <i>Yersinia</i>

David Balderas,
Erin Mettert,
Hanh N. Lam,
Rajdeep Banerjee,
Tomas Gverzdys,
Pablo Alvarez,
Geetha Saarunya,
Natasha Tanner,
Adam Zoubedi,
Yahan Wei,
Patricia J. Kiley,
Victoria Auerbuch

Affiliations

David Balderas: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Erin Mettert: Department of Biomolecular Chemistry, University of Wisconsin—Madison, Madison, Wisconsin, USA
Hanh N. Lam: ORCiD; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Rajdeep Banerjee: Department of Biomolecular Chemistry, University of Wisconsin—Madison, Madison, Wisconsin, USA
Tomas Gverzdys: Department of Biomolecular Chemistry, University of Wisconsin—Madison, Madison, Wisconsin, USA
Pablo Alvarez: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Geetha Saarunya: Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA
Natasha Tanner: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Adam Zoubedi: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Yahan Wei: Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA
Patricia J. Kiley: Department of Biomolecular Chemistry, University of Wisconsin—Madison, Madison, Wisconsin, USA
Victoria Auerbuch: ORCiD; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA

DOI: https://doi.org/10.1128/mBio.00633-21
Journal volume & issue: Vol. 12, no. 3

Abstract

Read online

How bacteria adapt to the changing environment within the host is critical for their ability to survive and cause disease. For example, the mammalian host severely restricts iron availability to limit bacterial growth, referred to as nutritional immunity.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal