Nature Communications (Jun 2018)

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta

  • Chloé S. Baron,
  • Lennart Kester,
  • Anna Klaus,
  • Jean-Charles Boisset,
  • Roshana Thambyrajah,
  • Laurent Yvernogeau,
  • Valérie Kouskoff,
  • Georges Lacaud,
  • Alexander van Oudenaarden,
  • Catherine Robin

DOI
https://doi.org/10.1038/s41467-018-04893-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells in vertebrate embryo aortas. Here, the authors perform single-cell RNA-sequencing of cells isolated from embryonic mouse aortas to identify genes and transcription factor networks activated during the endothelial-to-haematopoietic switch.