Connecting the dots – A systematic review on coherence analysis in dystonia

S.A.J.E.A. Lagerweij; M. Smit; L.M. Centen; J.M.C. van Dijk; M.E. van Egmond; J.W. Elting; M.A.J. Tijssen

Neurobiology of Disease (Oct 2024)

Connecting the dots – A systematic review on coherence analysis in dystonia

S.A.J.E.A. Lagerweij,
M. Smit,
L.M. Centen,
J.M.C. van Dijk,
M.E. van Egmond,
J.W. Elting,
M.A.J. Tijssen

Affiliations

S.A.J.E.A. Lagerweij: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands
M. Smit: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands
L.M. Centen: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands
J.M.C. van Dijk: Departments of Neurosurgery, University Medical Center Groningen. University of Groningen, the Netherlands
M.E. van Egmond: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Departments of Clinical Neurophysiology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands
J.W. Elting: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Departments of Clinical Neurophysiology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands
M.A.J. Tijssen: Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands; Corresponding author at: Department of Neurology, University Medical Center Groningen, 9700RB Groningen, The Netherlands.

Journal volume & issue: Vol. 200
p. 106616

Abstract

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Background: Increased 4–12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia. Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG). The aim of this study is to perform a systematic review on the use of coherence analysis for clinical assessment and treatment of dystonia. Methods: A systematic review was performed on a search in Embase and PubMed on June 28th, 2023. All studies incorporating coherence analysis and an adult dystonia cohort were included. Three authors evaluated the eligibility of the articles. Quality was assessed using the QUADAS-2 checklist. Results: A total of 41 articles were included, with data of 395 adult dystonia patients. In the selected records, six different types of coherence were investigated: corticocortical, corticopallidal, corticomuscular, pallidopallidal, pallidomuscular, and intermuscular coherence. Various types of 4–12 coherence were found to be increased in all dystonia subtypes. Conclusion: There is increased 4–12 Hz coherence found between the cortex, basal ganglia, and affected muscles in all dystonia subtypes. However, the relationship between 4-12 Hz coherence and the dystonic clinical state has not been established. DBS treatment leads to a reduction of 4–12 Hz coherence. In combination with the results of this review, the 4–12 Hz frequency band can be used as a promising phenomenon for the development of a biomarker.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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