Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

Alex W. Wessel; Michael P. Doyle; Taylor B. Engdahl; Jessica Rodriguez; James E. Crowe; Michael S. Diamond

doi:10.1128/mBio.02440-21

mBio (Oct 2021)

Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus Infection

Alex W. Wessel,
Michael P. Doyle,
Taylor B. Engdahl,
Jessica Rodriguez,
James E. Crowe,
Michael S. Diamond

Affiliations

Alex W. Wessel: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA
Michael P. Doyle: Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Taylor B. Engdahl: ORCiD; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Jessica Rodriguez: Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
James E. Crowe: ORCiD; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Michael S. Diamond: ORCiD; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

DOI: https://doi.org/10.1128/mBio.02440-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worsening of disease.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal