Nature Communications (Jun 2016)
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
- Rachel Barrow-McGee,
- Naoki Kishi,
- Carine Joffre,
- Ludovic Ménard,
- Alexia Hervieu,
- Bakhouche A. Bakhouche,
- Alejandro J. Noval,
- Anja Mai,
- Camilo Guzmán,
- Luisa Robbez-Masson,
- Xavier Iturrioz,
- James Hulit,
- Caroline H. Brennan,
- Ian R. Hart,
- Peter J. Parker,
- Johanna Ivaska,
- Stéphanie Kermorgant
Affiliations
- Rachel Barrow-McGee
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Naoki Kishi
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Carine Joffre
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Ludovic Ménard
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Alexia Hervieu
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Bakhouche A. Bakhouche
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Alejandro J. Noval
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Anja Mai
- University of Turku, Centre for Biotechnology and VTT Technical Research Centre of Finland
- Camilo Guzmán
- University of Turku, Centre for Biotechnology and VTT Technical Research Centre of Finland
- Luisa Robbez-Masson
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Xavier Iturrioz
- Protein Phosphorylation Laboratory, Francis Crick Institute
- James Hulit
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Caroline H. Brennan
- School of Biological and Chemical Sciences, Queen Mary University of London
- Ian R. Hart
- Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Peter J. Parker
- Protein Phosphorylation Laboratory, Francis Crick Institute
- Johanna Ivaska
- University of Turku, Centre for Biotechnology and VTT Technical Research Centre of Finland
- Stéphanie Kermorgant
- Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- DOI
- https://doi.org/10.1038/ncomms11942
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 18
Abstract
Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes.
