eIF6 rebinding dynamically couples ribosome maturation and translation

Pekka Jaako; Alexandre Faille; Shengjiang Tan; Chi C. Wong; Norberto Escudero-Urquijo; Pablo Castro-Hartmann; Penny Wright; Christine Hilcenko; David J. Adams; Alan J. Warren

doi:10.1038/s41467-022-29214-7

Nature Communications (Mar 2022)

eIF6 rebinding dynamically couples ribosome maturation and translation

Pekka Jaako,
Alexandre Faille,
Shengjiang Tan,
Chi C. Wong,
Norberto Escudero-Urquijo,
Pablo Castro-Hartmann,
Penny Wright,
Christine Hilcenko,
David J. Adams,
Alan J. Warren

Affiliations

Pekka Jaako: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Alexandre Faille: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Shengjiang Tan: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Chi C. Wong: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Norberto Escudero-Urquijo: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Pablo Castro-Hartmann: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
Penny Wright: Department of Pathology, Cambridge University Hospitals
Christine Hilcenko: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building
David J. Adams: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Genome Campus
Alan J. Warren: Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Keith Peters Building

DOI: https://doi.org/10.1038/s41467-022-29214-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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