Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts

Tyler W. Doughty; Iván Domenzain; Aaron Millan-Oropeza; Noemi Montini; Philip A. de Groot; Rui Pereira; Jens Nielsen; Céline Henry; Jean-Marc G. Daran; Verena Siewers; John P. Morrissey

doi:10.1038/s41467-020-16073-3

Nature Communications (May 2020)

Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts

Tyler W. Doughty,
Iván Domenzain,
Aaron Millan-Oropeza,
Noemi Montini,
Philip A. de Groot,
Rui Pereira,
Jens Nielsen,
Céline Henry,
Jean-Marc G. Daran,
Verena Siewers,
John P. Morrissey

Affiliations

Tyler W. Doughty: Department of Biology and Biological Engineering, Chalmers University of Technology
Iván Domenzain: Department of Biology and Biological Engineering, Chalmers University of Technology
Aaron Millan-Oropeza: Plateforme d’Analyse Protéomique Paris Sud-Ouest (PAPPSO), INRAE, MICALIS Institute, Université Paris-Saclay
Noemi Montini: School of Microbiology, Environmental Research Institute and APC Microbiome Ireland, University College Cork
Philip A. de Groot: Department of Biotechnology, Delft University of Technology, Van der Maasweg 9
Rui Pereira: Department of Biology and Biological Engineering, Chalmers University of Technology
Jens Nielsen: Department of Biology and Biological Engineering, Chalmers University of Technology
Céline Henry: Plateforme d’Analyse Protéomique Paris Sud-Ouest (PAPPSO), INRAE, MICALIS Institute, Université Paris-Saclay
Jean-Marc G. Daran: Department of Biotechnology, Delft University of Technology, Van der Maasweg 9
Verena Siewers: Department of Biology and Biological Engineering, Chalmers University of Technology
John P. Morrissey: School of Microbiology, Environmental Research Institute and APC Microbiome Ireland, University College Cork

DOI: https://doi.org/10.1038/s41467-020-16073-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Fermentation parameters of industrial processes are often not the ideal growth conditions for industrial microbes. Here, the authors reveal that young genes are more responsive to environmental stress than ancient genes using a new gene age assignment method and provide targeted genes for metabolic engineering.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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