Nature Communications (Jul 2021)
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
- Caterina Prelli Bozzo,
- Rayhane Nchioua,
- Meta Volcic,
- Lennart Koepke,
- Jana Krüger,
- Desiree Schütz,
- Sandra Heller,
- Christina M. Stürzel,
- Dorota Kmiec,
- Carina Conzelmann,
- Janis Müller,
- Fabian Zech,
- Elisabeth Braun,
- Rüdiger Groß,
- Lukas Wettstein,
- Tatjana Weil,
- Johanna Weiß,
- Federica Diofano,
- Armando A. Rodríguez Alfonso,
- Sebastian Wiese,
- Daniel Sauter,
- Jan Münch,
- Christine Goffinet,
- Alberto Catanese,
- Michael Schön,
- Tobias M. Boeckers,
- Steffen Stenger,
- Kei Sato,
- Steffen Just,
- Alexander Kleger,
- Konstantin M. J. Sparrer,
- Frank Kirchhoff
Affiliations
- Caterina Prelli Bozzo
- Institute of Molecular Virology, Ulm University Medical Center
- Rayhane Nchioua
- Institute of Molecular Virology, Ulm University Medical Center
- Meta Volcic
- Institute of Molecular Virology, Ulm University Medical Center
- Lennart Koepke
- Institute of Molecular Virology, Ulm University Medical Center
- Jana Krüger
- Department of Internal Medicine I, Ulm University Medical Center
- Desiree Schütz
- Institute of Molecular Virology, Ulm University Medical Center
- Sandra Heller
- Department of Internal Medicine I, Ulm University Medical Center
- Christina M. Stürzel
- Institute of Molecular Virology, Ulm University Medical Center
- Dorota Kmiec
- Institute of Molecular Virology, Ulm University Medical Center
- Carina Conzelmann
- Institute of Molecular Virology, Ulm University Medical Center
- Janis Müller
- Institute of Molecular Virology, Ulm University Medical Center
- Fabian Zech
- Institute of Molecular Virology, Ulm University Medical Center
- Elisabeth Braun
- Institute of Molecular Virology, Ulm University Medical Center
- Rüdiger Groß
- Institute of Molecular Virology, Ulm University Medical Center
- Lukas Wettstein
- Institute of Molecular Virology, Ulm University Medical Center
- Tatjana Weil
- Institute of Molecular Virology, Ulm University Medical Center
- Johanna Weiß
- Institute of Molecular Virology, Ulm University Medical Center
- Federica Diofano
- Department of Internal Medicine II (Cardiology), Ulm University
- Armando A. Rodríguez Alfonso
- Core Facility of Functional Peptidomics, Ulm University Medical Center
- Sebastian Wiese
- Core Unit of Mass Spectrometry and Proteomics, Ulm University Medical Center
- Daniel Sauter
- Institute of Molecular Virology, Ulm University Medical Center
- Jan Münch
- Institute of Molecular Virology, Ulm University Medical Center
- Christine Goffinet
- Institute of Virology, Charité—Universitätsmedizin Berlin
- Alberto Catanese
- Institute for Anatomy and Cell Biology, Ulm University
- Michael Schön
- Institute for Anatomy and Cell Biology, Ulm University
- Tobias M. Boeckers
- Institute for Anatomy and Cell Biology, Ulm University
- Steffen Stenger
- Institute of Medical Microbiology and Hygiene, Ulm University Medical Center
- Kei Sato
- Institute of Medical Science, The University of Tokyo
- Steffen Just
- Department of Internal Medicine II (Cardiology), Ulm University
- Alexander Kleger
- Department of Internal Medicine I, Ulm University Medical Center
- Konstantin M. J. Sparrer
- Institute of Molecular Virology, Ulm University Medical Center
- Frank Kirchhoff
- Institute of Molecular Virology, Ulm University Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-24817-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.
