Endoscopy International Open ()

GLP-1 Receptor Agonist Use Does Not Increase the Risk of Respiratory Complications Post-Endoscopy

  • Jena Velji-Ibrahim,
  • Piyush Nathani,
  • Harsh K Patel,
  • Prateek Sharma

DOI
https://doi.org/10.1055/a-2487-2937

Abstract

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Background and study aims: Data on respiratory complications associated with GLP-1 receptor agonist (GLP-1 RA) use before endoscopic procedures is limited. Methods: We conducted a retrospective cohort study using TriNetX in adults with diabetes or obesity on GLP-1 RAs within three months of endoscopy, comparing them to non-GLP-1 RA users. Propensity score matching and Cox proportional hazards models assessed outcomes. Results: Among 46,948 patients, no significant differences in post-endoscopy aspiration pneumonitis (HR 0.92, 95% CI: 0.54-1.56) or pneumonia (HR 1.01, 95% CI: 0.83-1.24) were found between groups. Conclusion: GLP-1 RA use before endoscopy does not increase respiratory complications, supporting continued preoperative medication use.