Cell Reports (Jun 2024)

Satiety controls behavior in Hydra through an interplay of pre-enteric and central nervous system-like neuron populations

  • Christoph Giez,
  • Christopher Noack,
  • Ehsan Sakib,
  • Lisa-Marie Hofacker,
  • Urska Repnik,
  • Marc Bramkamp,
  • Thomas C.G. Bosch

Journal volume & issue
Vol. 43, no. 6
p. 114210

Abstract

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Summary: Hunger and satiety can have an influence on decision-making, sensory processing, and motor behavior by altering the internal state of the brain. This process necessitates the integration of peripheral sensory stimuli into the central nervous system. Here, we show how animals without a central nervous system such as the cnidarian Hydra measure and integrate satiety into neuronal circuits and which specific neuronal populations are involved. We demonstrate that this simple nervous system, previously referred to as diffuse, has an endodermal subpopulation (N4) similar to the enteric nervous system (feeding-associated behavior) and an ectodermal population (N3) that performs central nervous system-like functions (physiology/motor). This view of a supposedly simple nervous system could open an important window into the origin of more complex nervous systems.

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