EFFECTS OF MELAXEN ON THE INDICES OF LIPID PEROXIDATION AND ANTIOXIDANT DEFFENCE IN EXPERIMENT IN CHRONIC ODONTOGENIC OSTEOMYELITIS OF JAWS

Abstract

The study was performed on 50 male Wistar rats, weighing 200–300 grams. A model of odontogenic mandibular osteomyelitis was created in all the animals, except the background group. In the control group, the standard treatment of this pathology was performed. In addition to the standard therapy, the experimental group of rats was injected with the drug Melaxen. On the 40rd, 45th, 50th, 55th days of the experiment, the indices of lipid peroxidation (LPO) and antioxidant protection were studied to determine the stage of inflammation development and the formation of protective reactions of the body. It has been shown that standard therapy of odontogenic osteomyelitis contributes to a certain decrease in the activity of oxidative stress enzymes and an increase in LPO. The use of the drug «Melaxen» led to a significantly more pronounced decrease in indicators of LPO and activation of antioxidant protection.

Keywords

• одонтогенный остеомиелит
• перекисное окисление липидов
• антиоксидантная защита