Research and Reports in Tropical Medicine (Feb 2024)
The Burden and Risk Factors of Helicobacter Pylori Infection Among Government Employees Who Clinically Complain of Indigestion but Allergic Diseases in Southeastern Ethiopia: A Multi-Institution Cross-Sectional Study
Abstract
Taye Kebede,1,2 Hagos Ashenafi2 1Department of Biomedical Sciences and Immunology, Madda Walabu University, Bale-Robe, Oromia Regional State, Ethiopia; 2Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Addis Ababa Administration City, EthiopiaCorrespondence: Taye Kebede, Department of Biomedical Sciences and Immunology, College of Natural Sciences, Madda Walabu University, Bale-Robe, Bale Zone, Oromia Regional State, Ethiopia, Tel +251 0911 355 335, Email [email protected]: Helicobacter pylori (H. pylori) is believed to have spread from East Africa, but its burden is still unknown in less privileged regions of Ethiopia. Indigestion is an upset stomach, upper abdomen discomfort, heartburn, and bloating. This study evaluated the burden and risk factors for H. pylori infection among government employees who clinically complained of indigestion but allergic diseases in five public health institutions in Southeastern Ethiopia.Methods: A health facilities-based cross-sectional survey study was conducted in Southeastern Ethiopia from March to November 2022, employing cluster sampling. Blood specimens, clinical data, and semi-structured questionnaires about risk factors were collected. Data analysis was conducted using descriptive, bivariate, and multivariable logistic regression in STATA software, Windows version 16.1.Results: The overall prevalence of infection was found to be 77.6%. The sampled health institution (ρ-value < 0.05), engagement in sideline business (ρ-value < 0.05), sharing local spoon on meal [AOR = 39.30; CI:19.52 − 78.31; ρ-value < 0.001], admitting “Gursha” during meal [AOR = 71.48; CI:3.99 − 1279.77; ρ-value < 0.05], the toilet type [AOR = 1410.98; CI:121.16 − 16,431.19; ρ-value < 0.001], alcohol drinking [AOR = 15.15; CI:1.90 − 120.62; ρ-value < 0.05], sleeping hours length [AOR = 15.01; CI:13.48– 55.96; ρ-value < 0.001], chewing Khat [AOR = 76.73; CI:8.57– 687.07; ρ-value < 0.001], and regular hand washing before eating [AOR = 0.15; CI:0.12– 0.19; ρ-value < 0.05] were the independent predictors of H. pylori infection.Conclusion: The prevalence rate of H. pylori infection in Southeastern Ethiopia is agonizingly high, exceeding the world average by 27.6%, the first report, and seems to be one of the neglected infectious diseases. Hence, the Oromia Region Health Bureau should reinvigorate the basic infectious disease control methods, establish routine laboratory diagnostic platforms, and intervene in selected societal practices spreading infections.Keywords: Burden, determinants of Helicobacter pylori infection, government employees, indigestion, allergic diseases, Southeastern Ethiopia
