External stimulation: A potential therapeutic strategy for tendon-bone healing

Shijie Fu; Shijie Fu; Shijie Fu; Yujian Lan; Guoyou Wang; Dingsu Bao; Bo Qin; Qiu Zheng; Huan Liu; Vincent Kam Wai Wong

doi:10.3389/fbioe.2023.1150290

Frontiers in Bioengineering and Biotechnology (Mar 2023)

External stimulation: A potential therapeutic strategy for tendon-bone healing

Shijie Fu,
Shijie Fu,
Shijie Fu,
Yujian Lan,
Guoyou Wang,
Dingsu Bao,
Bo Qin,
Qiu Zheng,
Huan Liu,
Vincent Kam Wai Wong

Affiliations

Shijie Fu: Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China
Shijie Fu: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Shijie Fu: Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China
Yujian Lan: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Guoyou Wang: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Dingsu Bao: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Bo Qin: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Qiu Zheng: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Huan Liu: Department of Orthopedics, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China
Vincent Kam Wai Wong: Dr. Neher’s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China

DOI: https://doi.org/10.3389/fbioe.2023.1150290
Journal volume & issue: Vol. 11

Abstract

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Injuries at the tendon-bone interface are very common in the field of sports medicine, and healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can seriously affect a patient’s quality of life, so it is essential to restore stability and promote healing of the tendon-bone interface. In addition to surgical treatment, the healing of tendons and bones can also be properly combined with extracorporeal stimulation therapy during the recovery process. In this review, we discuss the effects of extracorporeal shock waves (ESWs), low-intensity pulsed ultrasound (LIPUS), and mechanical stress on tendon-bone healing, focusing on the possible mechanisms of action of mechanical stress on tendon-bone healing in terms of transcription factors and biomolecules. The aim is to provide possible therapeutic approaches for subsequent clinical treatment.

Published in Frontiers in Bioengineering and Biotechnology

ISSN: 2296-4185 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Biotechnology
Website: http://www.frontiersin.org/bioengineering_and_biotechnology

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Abstract

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